Voranigo (vorasidenib) [product monograph]. HC.

Regulatory approval published by the Health Canada.

Citation

Servier Canada Inc. Voranigo (vorasidenib) [product monograph]. Health Canada website. https://pdf.hres.ca/dpd_pm/00076841.PDF. Published August 2024. Accessed June 2025.

View API

Regulatory approvals

Approved indications from this document for cancer drugs containing at least one biomarker.

Indication Statements
VORANIGO (vorasidenib tablets) is indicated for the treatment of Grade 2a astrocytoma or oligodendroglioma with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation or isocitrate dehydrogenase-2 (IDH2) mutation in adults and pediatric patients aged 12 years and older following surgical intervention. 20

Therapeutic response

Precision oncology relationships for therapeutic response derived from this document.

Type Biomarker(s) Cancer type Therapy(ies)
Sensitivity (+) IDH1 p.R132C Astrocytoma Vorasidenib HC
Sensitivity (+) IDH1 p.R132G Astrocytoma Vorasidenib HC
Sensitivity (+) IDH1 p.R132H Astrocytoma Vorasidenib HC
Sensitivity (+) IDH1 p.R132L Astrocytoma Vorasidenib HC
Sensitivity (+) IDH1 p.R132S Astrocytoma Vorasidenib HC
Sensitivity (+) IDH2 p.R172K Astrocytoma Vorasidenib HC
Sensitivity (+) IDH2 p.R172M Astrocytoma Vorasidenib HC
Sensitivity (+) IDH2 p.R172G Astrocytoma Vorasidenib HC
Sensitivity (+) IDH2 p.R172S Astrocytoma Vorasidenib HC
Sensitivity (+) IDH2 p.R172W Astrocytoma Vorasidenib HC
Sensitivity (+) IDH1 p.R132C Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH1 p.R132G Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH1 p.R132H Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH1 p.R132L Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH1 p.R132S Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH2 p.R172K Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH2 p.R172M Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH2 p.R172G Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH2 p.R172S Oligodendroglioma Vorasidenib HC
Sensitivity (+) IDH2 p.R172W Oligodendroglioma Vorasidenib HC