Vorasidenib

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Therapy type: Targeted therapy

Therapy strategy: IDH1/2 inhibition

Mappings

NCI Thesaurus: Vorasidenib (ncit:C152914)

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Therapeutic response

Precision oncology relationships for therapeutic response involving this therapy.

Type	Biomarker(s)	Cancer type	Therapy(ies)
Sensitivity (+)	IDH1 p.R132C	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132G	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132H	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132L	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132S	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172K	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172M	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172G	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172S	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172W	Astrocytoma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132C	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132G	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132H	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132L	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132S	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172K	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172M	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172G	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172S	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH2 p.R172W	Oligodendroglioma	Vorasidenib	FDA
Sensitivity (+)	IDH1 p.R132C	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132G	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132H	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132L	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132S	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172K	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172M	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172G	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172S	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172W	Astrocytoma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132C	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132G	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132H	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132L	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH1 p.R132S	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172K	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172M	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172G	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172S	Oligodendroglioma	Vorasidenib	HC
Sensitivity (+)	IDH2 p.R172W	Oligodendroglioma	Vorasidenib	HC